Newer non sedating antihistamines

receptors are commonly classified as first-generation or new-generation antihistamines based on their frequent sedating effect at therapeutic doses (1). Claritin, loratadine tablets, rapid dissolve tongue tablets, syrup [product monograph].

The “newer-generation” antihistamines, also known as second- or third-generation antihistamines, include astemizole, cetirizine, desloratadine, fexofenadine, loratadine and terfenadine, and were developed as non-sedating alternatives to the first-generation compounds. Reactine, cetirizine hydrochloride tablets, syrup [product monograph]. Pointe-Claire (QC): Schering Canada Inc; 2001 Jun 15. Claritin Extra, loratadine and pseudoephedrine repetabs tablets [product monograph].

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Cetirizine is available as both a nonprescription (5 and 10 mg) and prescription (20 mg) drug. Usually, more than a single report is required to generate a signal, depending upon the seriousness of the event and the quality of the information”.From their respective dates of marketing in Canada to September 2002, Health Canada received 20 reports of suspected convulsive disorders associated with the use of loratadine (9 reports), cetirizine (7 reports) and fexofenadine (4 reports). There have been no reports of suspected convulsive disorders associated with desloratadine at this time. Most cases of allergic rhinitis respond to pharmacotherapy.Patients with intermittent symptoms are often treated adequately with oral antihistamines, decongestants, or both as needed.

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